Investigating cycle-to-cycle variation and the impact of endometrial injury through differential gene expression analysis.

Abstract

STUDY QUESTION: Does endometrial gene expression change across consecutive cycles and after endometrial injury? SUMMARY ANSWER: Although paired endometrial samples collected from the same woman across two consecutive cycles show greater similarity in molecular profile compared to samples from different women, endometrial injury in the preceding cycle did not result in any significant differential gene expression. WHAT IS KNOWN ALREADY: Uterine receptivity is a crucial factor influencing pregnancy rates in IVF. The potential benefits of endometrial injury in enhancing receptivity, as well as the effectiveness of genomic endometrial receptivity tests in predicting uterine receptivity are subje..